Surface-Linked Liposomal Antigen Antibody Production Induced by T Cell-Independent Regulation of IgE
نویسندگان
چکیده
منابع مشابه
Production and Characterization of a Monoclonal Antibody against an Antigen on the Surface of Non-Small Cell Carcinoma of the Lung
Background: Lung carcinoma is a multiple type cancer comprising of small cell and non-small cell carcinomas (NSCLC). For therapeutic and diagnostic purposes, serum monoclonal antibodies have been produced against lung cancer. Objective: To charac-terize a murine monoclonal antibody (ME3D11) reactive with human NSCLC. Methods: A murine monoclonal antibody (ME3D11) reactive with human NSCLC was s...
متن کاملInterleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells.
Recently the cDNA encoding interleukin 13 (IL-13), a T-cell-derived cytokine, was cloned and expressed. The present study demonstrates that IL-13 induces IgG4 and IgE synthesis by human B cells. IL-13-induced IgG4 and IgE synthesis by unfractionated peripheral blood mononuclear cells and highly purified B cells cultured in the presence of activated CD4+ T cells or their membranes. IL-13-induced...
متن کاملCD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells
A novel pathway of IgE-B cell differentiation has been identified. Engagement of the B cell antigen CD40 by F(ab')2 fragments of monoclonal antibody (mAb) 626.1 in the presence of recombinant interleukin 4 (rIL-4) induced intense IgE synthesis, but modest IgG synthesis, by highly purified human B cells. Surface IgE- B cells isolated by cell sorting were induced to produce IgE by mAb 626.1 and I...
متن کاملHAPTEN-SPECIFIC IgE ANTIBODY RESPONSES IN MICE I. SECONDAR'x r IgE RESPONSES IN IRRADIATED RECIPIENTS OF SYNGENEIC PRIMED SPLEEN
The induction of humoral immune responses to a variety of antigens requires the cooperative participation of both thymus-derived (T) and bone marrowderived (B) lymphocytes. The former cells exert very definite regulatory influences on the responses of IgM and IgG B lymphocyte precursors of antibody-forming cells with respect to triggering and differentiative events after exposure to antigen (re...
متن کاملRegulation of reaginic antibody production in mice. I. Suppression by antigen of IgE antibody production in vitro
Regulation of IgE production by antigen in a primed murine splenic lymphocyte culture system was described. Maximum IgE antibody production was found to occur when cells were cultured in the absence of exogenously added antigen. A cells and T lymphocytes did not affect the production of anti-DNP IgE antibody. By using a hapten-carrier antigen system (DNP-EA) for priming mice in vivo, it was fou...
متن کامل